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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C28860
http://purl.obolibrary.org/obo/NCIT_C28860
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|---|---|
| Preferred Name | Bcl-Xs Adenovirus Vaccine |
| Definitions |
A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04) |
|---|---|
| prefLabel | Bcl-Xs Adenovirus Vaccine
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| label | Bcl-Xs Adenovirus Vaccine
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| code | C28860
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| prefixIRI | NCIT:C28860
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| in_subset | |
| Preferred_Name | Bcl-Xs Adenovirus Vaccine
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| Maps_To | Bcl-Xs Adenovirus Vaccine
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| NSC Number | 689513
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| Legacy Concept Name | Bcl-Xs_Adenovirus_Vaccine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C1511078
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