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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C28802
http://purl.obolibrary.org/obo/NCIT_C28802
|
|---|---|
| Preferred Name | Aphidicoline Glycinate |
| Definitions |
A tetracyclic diterpene antibiotic isolated from the fungus Cephalosporium aphidicola and other fungal species with potential antineoplastic activity. Aphidicoline glycinate blocks the cell cycle at early S-phase by specifically inhibiting DNA polymerases in eukaryotic cells, induces apoptosis, and stops the growth of eukaryotic cells and certain viruses by selectively inhibiting DNA polymerase II or viral-induced DNA polymerases. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A tetracyclic diterpene antibiotic isolated from the fungus Cephalosporium aphidicola and other fungal species with potential antineoplastic activity. Aphidicoline glycinate blocks the cell cycle at early S-phase by specifically inhibiting DNA polymerases in eukaryotic cells, induces apoptosis, and stops the growth of eukaryotic cells and certain viruses by selectively inhibiting DNA polymerase II or viral-induced DNA polymerases. (NCI04) |
|---|---|
| prefLabel | Aphidicoline Glycinate
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| label | Aphidicoline Glycinate
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| code | C28802
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| prefixIRI | NCIT:C28802
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| in_subset | |
| Preferred_Name | Aphidicoline Glycinate
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| Maps_To | Aphidicoline Glycinate
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| Legacy Concept Name | Aphidicoline_Glycinate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1516035
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