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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C288
http://purl.obolibrary.org/obo/NCIT_C288
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|---|---|
| Preferred Name | Azacitidine |
| Definitions |
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04) |
|---|---|
| prefLabel | Azacitidine
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| label | Azacitidine
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| CHEBI_ID | CHEBI:2038
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| PDQ_Closed_Trial_Search_ID | 39153
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| code | C288
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| Has_Target | |
| prefixIRI | NCIT:C288
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| in_subset |
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| Display_Name | Azacitidine
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| Preferred_Name | Azacitidine
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| FDA_UNII_Code | M801H13NRU
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C8H12N4O5
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| Maps_To | Azacitidine
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| CAS_Registry | 320-67-2
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| NSC Number | 102816
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| NCI_Drug_Dictionary_ID | 39153
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| Legacy Concept Name | Azacitidine
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| type | |
| ALT_DEFINITION | A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39153
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| Accepted_Therapeutic_Use_For | Myelodysplastic Syndrome; acute myeloid leukemia
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0004475
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