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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C28789
http://purl.obolibrary.org/obo/NCIT_C28789
|
|---|---|
| Preferred Name | 9-Ethyl 6-Mercaptopurine |
| Definitions |
A synthetic alkyl derivative prodrug of the antineoplastic agent 6-mercaptopurine (6-MP). In vivo, 9-ethyl 6-mercaptopurine appears to be converted to 6-MP, which substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic alkyl derivative prodrug of the antineoplastic agent 6-mercaptopurine (6-MP). In vivo, 9-ethyl 6-mercaptopurine appears to be converted to 6-MP, which substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. (NCI04) |
|---|---|
| prefLabel | 9-Ethyl 6-Mercaptopurine
|
| label | 9-Ethyl 6-Mercaptopurine
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| code | C28789
|
| prefixIRI | NCIT:C28789
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| in_subset | |
| Preferred_Name | 9-Ethyl 6-Mercaptopurine
|
| Maps_To | 9-Ethyl 6-Mercaptopurine
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| CAS_Registry | 5427-20-3
|
| NSC Number | 14575
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| Legacy Concept Name | _9-Ethyl_6-Mercaptopurine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0626019
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