loading...| Preferred Name |
High Affinity Nerve Growth Factor Receptor |
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| Synonyms |
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| Definitions |
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C28558 |
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| code |
C28558 |
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| Contributing_Source |
CTRP |
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| definition |
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling. |
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| DesignNote |
NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways. |
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| Display_Name |
High Affinity Nerve Growth Factor Receptor |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
High Affinity Nerve Growth Factor Receptor |
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| Legacy Concept Name |
Neurotrophic_Tyrosine_Kinase_Receptor_Type-1 |
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| NCI_META_CUI |
CL1648602 |
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| OMIM_Number |
191315 |
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| Preferred_Name |
High Affinity Nerve Growth Factor Receptor |
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| prefixIRI |
NCIT:C28558 |
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| prefLabel |
High Affinity Nerve Growth Factor Receptor |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
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| Swiss_Prot |
P04629 |
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| subClassOf |