Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C28558
http://purl.obolibrary.org/obo/NCIT_C28558
|
|---|---|
| Preferred Name | High Affinity Nerve Growth Factor Receptor |
| Definitions |
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation, axonogenesis and receptor-mediated signaling. |
|---|---|
| prefLabel | High Affinity Nerve Growth Factor Receptor
|
| label | High Affinity Nerve Growth Factor Receptor
|
| NCI_META_CUI | CL1648602
|
| code | C28558
|
| prefixIRI | NCIT:C28558
|
| OMIM_Number | 191315
|
| in_subset | |
| Display_Name | High Affinity Nerve Growth Factor Receptor
|
| Preferred_Name | High Affinity Nerve Growth Factor Receptor
|
| Contributing_Source | CTRP
|
| Swiss_Prot | P04629
|
| Legacy Concept Name | Neurotrophic_Tyrosine_Kinase_Receptor_Type-1
|
| DesignNote | NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways.
|
| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |