Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C2830 http://purl.obolibrary.org/obo/NCIT_C2830
Preferred Name	Lontucirev
Definitions	An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of lontucirev-mediated tumor cell cytotoxicity. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of lontucirev-mediated tumor cell cytotoxicity. (NCI04)
prefLabel	Lontucirev
label	Lontucirev
PDQ_Closed_Trial_Search_ID	43035
code	C2830
prefixIRI	NCIT:C2830
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Lontucirev
FDA_UNII_Code	F1F4B2ILM1
Contributing_Source	FDA
Maps_To	Lontucirev
CAS_Registry	437981-77-6
NSC Number	688653
NCI_Drug_Dictionary_ID	43035
Legacy Concept Name	ONYX-015
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C49146 http://purl.obolibrary.org/obo/NCIT_C717
PDQ_Open_Trial_Search_ID	43035
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C0678040

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