Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2801
http://purl.obolibrary.org/obo/NCIT_C2801
|
|---|---|
| Preferred Name | Pyroxamide |
| Definitions |
A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04) |
|---|---|
| prefLabel | Pyroxamide
|
| label | Pyroxamide
|
| PDQ_Closed_Trial_Search_ID | 256405
|
| code | C2801
|
| prefixIRI | NCIT:C2801
|
| in_subset | |
| Preferred_Name | Pyroxamide
|
| FDA_UNII_Code | 12N86DSS23
|
| Contributing_Source | FDA
|
| Maps_To | Pyroxamide
|
| CAS_Registry | 382180-17-8
|
| NSC Number | 696085
|
| NCI_Drug_Dictionary_ID | 256405
|
| Legacy Concept Name | Pyroxamide
|
| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 256405
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0966748
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |