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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2722
http://purl.obolibrary.org/obo/NCIT_C2722
|
|---|---|
| Preferred Name | RAF Kinase Inhibitor L-779450 |
| Definitions |
A synthetic triarylimidazole with potential antineoplastic activity. As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic triarylimidazole with potential antineoplastic activity. As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04) |
|---|---|
| prefLabel | RAF Kinase Inhibitor L-779450
|
| label | RAF Kinase Inhibitor L-779450
|
| code | C2722
|
| prefixIRI | NCIT:C2722
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| in_subset | |
| Preferred_Name | RAF Kinase Inhibitor L-779450
|
| Maps_To | RAF Kinase Inhibitor L-779450
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| Legacy Concept Name | L-779450
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1517681
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