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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2721
http://purl.obolibrary.org/obo/NCIT_C2721
|
|---|---|
| Preferred Name | c-raf Antisense Oligonucleotide ISIS 5132 |
| Definitions |
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04) |
|---|---|
| prefLabel | c-raf Antisense Oligonucleotide ISIS 5132
|
| label | c-raf Antisense Oligonucleotide ISIS 5132
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| PDQ_Closed_Trial_Search_ID | 42994
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| code | C2721
|
| prefixIRI | NCIT:C2721
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| in_subset | |
| Preferred_Name | c-raf Antisense Oligonucleotide ISIS 5132
|
| FDA_UNII_Code | 48IAF3FDP3
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| Contributing_Source | FDA
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| Maps_To | c-raf Antisense Oligonucleotide ISIS 5132
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| CAS_Registry | 177075-18-2
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| NSC Number | 719336
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| NCI_Drug_Dictionary_ID | 42994
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| Legacy Concept Name | ISIS_5132
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42994
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0389883
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