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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2715
http://purl.obolibrary.org/obo/NCIT_C2715
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|---|---|
| Preferred Name | Telomerase Inhibitor FJ5002 |
| Definitions |
A derivative of rhodacyanine with potential antineoplastic activity. FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells. Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A derivative of rhodacyanine with potential antineoplastic activity. FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells. Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04) |
|---|---|
| label | Telomerase Inhibitor FJ5002
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| prefLabel | Telomerase Inhibitor FJ5002
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| Legacy Concept Name | FJ5002
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| in_subset | |
| Preferred_Name | Telomerase Inhibitor FJ5002
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| Is_Value_For_GDC_Property | |
| Maps_To | Telomerase Inhibitor FJ5002
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| UMLS_CUI | C0908717
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| prefixIRI | NCIT:C2715
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| subClassOf | |
| code | C2715
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| type | |
| Semantic_Type | Pharmacologic Substance
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