Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2713
http://purl.obolibrary.org/obo/NCIT_C2713
Preferred Name

Pelitinib
Definitions
A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.
prefLabel
Pelitinib
label
Pelitinib
CHEBI_ID
CHEBI:38927
PDQ_Closed_Trial_Search_ID
352165
code
C2713
Has_Target
prefixIRI
NCIT:C2713
in_subset
Display_Name
Pelitinib
Preferred_Name
Pelitinib
FDA_UNII_Code
X5DWL380Z6
Contributing_Source
CTRP
FDA
Chemical_Formula
C24H23ClFN5O2
Maps_To
Pelitinib
CAS_Registry
257933-82-7
NSC Number
729742
NCI_Drug_Dictionary_ID
352165
Legacy Concept Name
EKB-569
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called epidermal growth factor receptor inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
352165
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0961045
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display