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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2697
http://purl.obolibrary.org/obo/NCIT_C2697
|
|---|---|
| Preferred Name | Iodine I 131 Monoclonal Antibody CC49-deltaCH2 |
| Definitions |
A radioimmunoconjugate consisting of the humanized CH2 domain-deleted monoclonal antibody CC49 and iodine I 131 with antineoplastic activity. Monoclonal antibody CC49-deltaCH2 targets the tumor-associated glycoprotein 72 (TAG-72) that is expressed by a wide range of human neoplasms including colorectal, gastric, pancreatic, ovarian, endometrial, breast, non-small cell lung, and prostate cancers. Iodine I 131 monoclonal antibody CC49-deltaCH2 binds to tumor cells expressing TAG-72, selectively delivering a cytotoxic dose of beta and gamma radiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of the humanized CH2 domain-deleted monoclonal antibody CC49 and iodine I 131 with antineoplastic activity. Monoclonal antibody CC49-deltaCH2 targets the tumor-associated glycoprotein 72 (TAG-72) that is expressed by a wide range of human neoplasms including colorectal, gastric, pancreatic, ovarian, endometrial, breast, non-small cell lung, and prostate cancers. Iodine I 131 monoclonal antibody CC49-deltaCH2 binds to tumor cells expressing TAG-72, selectively delivering a cytotoxic dose of beta and gamma radiation. |
|---|---|
| prefLabel | Iodine I 131 Monoclonal Antibody CC49-deltaCH2
|
| label | Iodine I 131 Monoclonal Antibody CC49-deltaCH2
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| PDQ_Closed_Trial_Search_ID | 453590
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| code | C2697
|
| Has_Target | |
| prefixIRI | NCIT:C2697
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| in_subset |
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| Display_Name | Iodine I 131 Monoclonal Antibody CC49-deltaCH2
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| Preferred_Name | Iodine I 131 Monoclonal Antibody CC49-deltaCH2
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| Contributing_Source | CTRP
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| Maps_To | Iodine I 131 Monoclonal Antibody CC49-deltaCH2
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| NCI_Drug_Dictionary_ID | 453590
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| Legacy Concept Name | Iodine_I_131_Monoclonal_Antibody_CC49-deltaCH2
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 453590
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1134477
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