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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2692
http://purl.obolibrary.org/obo/NCIT_C2692
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|---|---|
| Preferred Name | Glycinamide Ribonucleotide Formyltransferase Inhibitor |
| Definitions |
Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest. |
|---|---|
| prefLabel | Glycinamide Ribonucleotide Formyltransferase Inhibitor
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| label | Glycinamide Ribonucleotide Formyltransferase Inhibitor
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| CHEBI_ID | CHEBI:63721
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| code | C2692
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| prefixIRI | NCIT:C2692
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| Preferred_Name | Glycinamide Ribonucleotide Formyltransferase Inhibitor
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| Legacy Concept Name | Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor
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| type | |
| ALT_DEFINITION | A drug that blocks DNA synthesis and may prevent tumor growth. It is being studied as a treatment for cancer.
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| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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| UMLS_CUI | C1512220
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