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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2688
http://purl.obolibrary.org/obo/NCIT_C2688
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|---|---|
| Preferred Name | Nab-paclitaxel |
| Definitions |
A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor. |
|---|---|
| prefLabel | Nab-paclitaxel
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| label | Nab-paclitaxel
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| PDQ_Closed_Trial_Search_ID | 38690
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| code | C2688
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| prefixIRI | NCIT:C2688
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| in_subset |
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| Display_Name | Nab-paclitaxel
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| Preferred_Name | Nab-paclitaxel
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| Contributing_Source | CTRP
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| Maps_To | Nab-paclitaxel
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| NSC Number | 736631
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| NCI_Drug_Dictionary_ID | 38690
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| Legacy Concept Name | ABI-007
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| type | |
| ALT_DEFINITION | A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. ABI-007 is a type of mitotic inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38690
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| Accepted_Therapeutic_Use_For | Metastatic breast cancer
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1134696
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