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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2679
http://purl.obolibrary.org/obo/NCIT_C2679
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|---|---|
| Preferred Name | Colchicine-Site Binding Agent ABT-751 |
| Definitions |
An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04) |
|---|---|
| prefLabel | Colchicine-Site Binding Agent ABT-751
|
| label | Colchicine-Site Binding Agent ABT-751
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| PDQ_Closed_Trial_Search_ID | 38646
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| code | C2679
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| Has_Target | |
| prefixIRI | NCIT:C2679
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| in_subset |
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| Display_Name | Colchicine-Site Binding Agent ABT-751
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| Preferred_Name | Colchicine-Site Binding Agent ABT-751
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| FDA_UNII_Code | WDT5V5OB9F
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Colchicine-Site Binding Agent ABT-751
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| CAS_Registry | 141430-65-1
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| NCI_Drug_Dictionary_ID | 38646
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| Legacy Concept Name | ABT-751
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38646
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1134654
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