loading...| Preferred Name |
Beta-Glucan |
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| Synonyms |
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| Definitions |
A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2678 |
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| ALT_DEFINITION |
A substance found in bacteria, plants, and certain foods, such as baker's yeast, cereal grains, and mushrooms. It is a type of polysaccharide that is made of a string of glucose (sugar) molecules joined together. Beta-glucan may stimulate the immune system and help kill cancer cells. It is being studied in the treatment of cancer. It is a type of biological response modifier. |
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| CHEBI_ID |
CHEBI:28793 |
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| code |
C2678 |
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| Contributing_Source |
CTRP |
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| definition |
A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04) |
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| Display_Name |
Beta-Glucan |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Beta-Glucan |
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| Legacy Concept Name |
Beta-Glucan |
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| Maps_To |
Beta-Glucan |
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| NCI_Drug_Dictionary_ID |
38642 |
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| PDQ_Closed_Trial_Search_ID |
38642 |
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| PDQ_Open_Trial_Search_ID |
38642 |
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| Preferred_Name |
Beta-Glucan |
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| prefixIRI |
NCIT:C2678 |
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| prefLabel |
Beta-Glucan |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C1134651 |
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| subClassOf |