Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2678
http://purl.obolibrary.org/obo/NCIT_C2678
|
|---|---|
| Preferred Name | Beta-Glucan |
| Definitions |
A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04) |
|---|---|
| prefLabel | Beta-Glucan
|
| label | Beta-Glucan
|
| CHEBI_ID | CHEBI:28793
|
| PDQ_Closed_Trial_Search_ID | 38642
|
| code | C2678
|
| prefixIRI | NCIT:C2678
|
| in_subset |
See more
See less
|
| Display_Name | Beta-Glucan
|
| Preferred_Name | Beta-Glucan
|
| Contributing_Source | CTRP
|
| Maps_To | Beta-Glucan
|
| NCI_Drug_Dictionary_ID | 38642
|
| Legacy Concept Name | Beta-Glucan
|
| type | |
| ALT_DEFINITION | A substance found in bacteria, plants, and certain foods, such as baker's yeast, cereal grains, and mushrooms. It is a type of polysaccharide that is made of a string of glucose (sugar) molecules joined together. Beta-glucan may stimulate the immune system and help kill cancer cells. It is being studied in the treatment of cancer. It is a type of biological response modifier.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38642
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C1134651
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |