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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2670
http://purl.obolibrary.org/obo/NCIT_C2670
|
|---|---|
| Preferred Name | MEK Inhibitor CI-1040 |
| Definitions |
An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation. |
|---|---|
| prefLabel | MEK Inhibitor CI-1040
|
| label | MEK Inhibitor CI-1040
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| PDQ_Closed_Trial_Search_ID | 38593
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| code | C2670
|
| prefixIRI | NCIT:C2670
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| in_subset | |
| Preferred_Name | MEK Inhibitor CI-1040
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| FDA_UNII_Code | R3K9Y00J04
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| Contributing_Source | FDA
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| Maps_To | MEK Inhibitor CI-1040
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| CAS_Registry | 212631-79-3
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| NCI_Drug_Dictionary_ID | 38593
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| Legacy Concept Name | CI-1040
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38593
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0769765
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