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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C26680
http://purl.obolibrary.org/obo/NCIT_C26680
|
|---|---|
| Preferred Name | NY-ESO-B |
| Definitions |
A tumor-associated antigen belonging to the family of immunogenic testicular proteins that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma; and restricted expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein. NY-ESO-1 elicits a strong, integrated humoral and cellular immune response in a high proportion of patients with NY-ESO-1-expressing tumors and is under investigation as a cancer immunotherapy agent.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A tumor-associated antigen belonging to the family of immunogenic testicular proteins that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma; and restricted expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein. NY-ESO-1 elicits a strong, integrated humoral and cellular immune response in a high proportion of patients with NY-ESO-1-expressing tumors and is under investigation as a cancer immunotherapy agent. |
|---|---|
| prefLabel | NY-ESO-B
|
| label | NY-ESO-B
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| PDQ_Closed_Trial_Search_ID | 257347
|
| code | C26680
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| prefixIRI | NCIT:C26680
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| in_subset | |
| Preferred_Name | NY-ESO-B
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| Maps_To | NY-ESO-B
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| NCI_Drug_Dictionary_ID | 257347
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| Legacy Concept Name | NY-ESO-B
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 257347
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| Semantic_Type | Immunologic Factor
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| UMLS_CUI | C1327762
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