Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C26676
http://purl.obolibrary.org/obo/NCIT_C26676
Preferred Name

Transferrin-CRM107
Definitions
A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). After binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting protein synthesis through ADP-ribosylation of elongation factor. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). After binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting protein synthesis through ADP-ribosylation of elongation factor. (NCI04)
prefLabel
Transferrin-CRM107
label
Transferrin-CRM107
PDQ_Closed_Trial_Search_ID
269064
code
C26676
prefixIRI
NCIT:C26676
in_subset
Preferred_Name
Transferrin-CRM107
Maps_To
Transferrin-CRM107
NCI_Drug_Dictionary_ID
269064
Legacy Concept Name
Transferrin-CRM107
type
ALT_DEFINITION
A substance being studied in the treatment of brain tumors. Transferrin-CRM107 is made by linking a diphtheria toxin to transferrin, a protein that binds to fast growing cells, such as tumor cells. The diphtheria toxin then kills the tumor cells. Transferrin-CRM107 is a type of immunotoxin.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
269064
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C0912205
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