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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C26669
http://purl.obolibrary.org/obo/NCIT_C26669
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|---|---|
| Preferred Name | Seocalcitol |
| Definitions |
A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated. |
|---|---|
| prefLabel | Seocalcitol
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| label | Seocalcitol
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| PDQ_Closed_Trial_Search_ID | 298863
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| code | C26669
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| prefixIRI | NCIT:C26669
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| in_subset | |
| Preferred_Name | Seocalcitol
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| FDA_UNII_Code | Q0OZ0D9223
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| Contributing_Source | FDA
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| Chemical_Formula | C30H46O3
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| Maps_To | Seocalcitol
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| CAS_Registry | 134404-52-7
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| NCI_Drug_Dictionary_ID | 298863
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| Legacy Concept Name | Seocalcitol
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called vitamin D analogs.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 298863
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0905598
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