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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C26663
http://purl.obolibrary.org/obo/NCIT_C26663
|
|---|---|
| Preferred Name | Pixantrone |
| Definitions |
A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. |
|---|---|
| label | Pixantrone
|
| prefLabel | Pixantrone
|
| Legacy Concept Name | Pixantrone
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| in_subset |
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| Preferred_Name | Pixantrone
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C17H19N5O2
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| Display_Name | Pixantrone
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| Maps_To | Pixantrone
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| Has_Target | |
| UMLS_CUI | C0253355
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| FDA_UNII_Code | F5SXN2KNMR
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| prefixIRI | NCIT:C26663
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| Has_Salt_Form | |
| code | C26663
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 144510-96-3
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