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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C26660
http://purl.obolibrary.org/obo/NCIT_C26660
|
|---|---|
| Preferred Name | Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704 |
| Definitions |
An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI04) |
|---|---|
| prefLabel | Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704
|
| label | Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704
|
| PDQ_Closed_Trial_Search_ID | 299464
|
| code | C26660
|
| Has_Target | |
| prefixIRI | NCIT:C26660
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| in_subset | |
| Preferred_Name | Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704
|
| Maps_To | Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704
|
| NCI_Drug_Dictionary_ID | 299464
|
| Legacy Concept Name | MLN2704
|
| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called antibody drug conjugates.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 299464
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1327945
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