Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C26652
http://purl.obolibrary.org/obo/NCIT_C26652
Preferred Name

Antisense Oligonucleotide GTI-2040
Definitions
A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)
prefLabel
Antisense Oligonucleotide GTI-2040
label
Antisense Oligonucleotide GTI-2040
PDQ_Closed_Trial_Search_ID
301635
code
C26652
Has_Target
prefixIRI
NCIT:C26652
in_subset
Display_Name
GTI-2040
Preferred_Name
Antisense Oligonucleotide GTI-2040
FDA_UNII_Code
5WY0FWR2CF
Contributing_Source
CTRP
FDA
Maps_To
Antisense Oligonucleotide GTI-2040
CAS_Registry
236391-66-5
NSC Number
722929
NCI_Drug_Dictionary_ID
301635
Legacy Concept Name
GTI-2040
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. It blocks the production of a protein called ribonucleotide reductase, which helps cells make DNA. This may kill cancer cells that need ribonucleotide reductase to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of ribonucleotide reductase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
301635
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C1142995
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