Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C2665 http://purl.obolibrary.org/obo/NCIT_C2665
Preferred Name	Edotecarin
Definitions	A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04)
prefLabel	Edotecarin
label	Edotecarin
PDQ_Closed_Trial_Search_ID	38537
code	C2665
prefixIRI	NCIT:C2665
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Edotecarin
FDA_UNII_Code	1V8X590XDP
Contributing_Source	FDA
Chemical_Formula	C29H28N4O11
Maps_To	Edotecarin
CAS_Registry	174402-32-5
NCI_Drug_Dictionary_ID	38537
Legacy Concept Name	Edotecarin
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1904
PDQ_Open_Trial_Search_ID	38537
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1328673

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