loading...| Preferred Name |
Interferon Regulatory Factor 3 |
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| Synonyms |
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| Definitions |
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral activity and interferon-stimulated response element promoter activation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C26625 |
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| code |
C26625 |
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| Contributing_Source |
CTRP |
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| definition |
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral activity and interferon-stimulated response element promoter activation. |
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| DesignNote |
IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (EntrezGene) |
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| Display_Name |
Interferon Regulatory Factor 3 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177415 http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Interferon Regulatory Factor 3 |
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| Legacy Concept Name |
Interferon_Regulatory_Factor-3 |
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| OMIM_Number |
603734 |
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| Preferred_Name |
Interferon Regulatory Factor 3 |
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| prefixIRI |
NCIT:C26625 |
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| prefLabel |
Interferon Regulatory Factor 3 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| Swiss_Prot |
Q14653 |
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| UMLS_CUI |
C0384768 |
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| subClassOf |