Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2662
http://purl.obolibrary.org/obo/NCIT_C2662
|
|---|---|
| Preferred Name | Topoisomerase-II-beta Inhibitor Racemic XK469 |
| Definitions |
The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05) |
|---|---|
| prefLabel | Topoisomerase-II-beta Inhibitor Racemic XK469
|
| label | Topoisomerase-II-beta Inhibitor Racemic XK469
|
| PDQ_Closed_Trial_Search_ID | 38517
|
| code | C2662
|
| Has_Target | |
| prefixIRI | NCIT:C2662
|
| in_subset |
See more
See less
|
| Display_Name | R(+)XK469
|
| Preferred_Name | Topoisomerase-II-beta Inhibitor Racemic XK469
|
| Contributing_Source | CTRP
|
| Maps_To | Topoisomerase-II-beta Inhibitor Racemic XK469
|
| NSC Number | 698215
|
| NCI_Drug_Dictionary_ID | 38517
|
| Legacy Concept Name | XK469
|
| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38517
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C0765292
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |