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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2652
http://purl.obolibrary.org/obo/NCIT_C2652
|
|---|---|
| Preferred Name | Rosopatamab |
| Definitions |
A humanized monoclonal antibody (MoAb) against the external domain of the Prostate-specific membrane antigen (PSMA), overexpressed in the malignant prostate and its metastases. Although PSMA is not a biomarker of disease progression, over-expression indicates an aggressive phenotype of the prostate cancer. Rosopatamab was generated by replacing murine Ig sequences with human ones, thereby MoAb huJ591can be administered to patients on multiple occasions over long time periods without inducing an immune response. Radiolabelled MoAb huJ591 may be used in immunotherapy of prostate cancer.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody (MoAb) against the external domain of the Prostate-specific membrane antigen (PSMA), overexpressed in the malignant prostate and its metastases. Although PSMA is not a biomarker of disease progression, over-expression indicates an aggressive phenotype of the prostate cancer. Rosopatamab was generated by replacing murine Ig sequences with human ones, thereby MoAb huJ591can be administered to patients on multiple occasions over long time periods without inducing an immune response. Radiolabelled MoAb huJ591 may be used in immunotherapy of prostate cancer. |
|---|---|
| prefLabel | Rosopatamab
|
| label | Rosopatamab
|
| PDQ_Closed_Trial_Search_ID | 38425
|
| code | C2652
|
| prefixIRI | NCIT:C2652
|
| in_subset | |
| Preferred_Name | Rosopatamab
|
| FDA_UNII_Code | 2TTE6SSR0J
|
| Contributing_Source | FDA
|
| Maps_To |
Monoclonal Antibody huJ591
Rosopatamab
|
| CAS_Registry | 2260767-49-3
|
| NCI_Drug_Dictionary_ID | 38425
|
| Legacy Concept Name | Monoclonal_Antibody_huJ591
|
| PubMedID_Primary_Reference | 14716739
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38425
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
|
| UMLS_CUI | C1134478
|
| Delete | Subject | Author | Type | Created |
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| No notes to display |