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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C26447
http://purl.obolibrary.org/obo/NCIT_C26447
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|---|---|
| Preferred Name | Galiximab |
| Definitions |
A chimeric IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chimeric IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. |
|---|---|
| label | Galiximab
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| prefLabel | Galiximab
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| Legacy Concept Name | IDEC-114_Monoclonal_Antibody
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| in_subset |
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| Preferred_Name | Galiximab
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| Is_Value_For_GDC_Property | |
| Display_Name | Galiximab
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| Maps_To | Galiximab
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| PDQ_Open_Trial_Search_ID | 285686
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| Has_Target | |
| UMLS_CUI | C1098262
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| FDA_UNII_Code | S9OX9692ZB
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| prefixIRI | NCIT:C26447
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| NCI_Drug_Dictionary_ID | 285686
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C26447
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of follicular non-Hodgkin lymphoma. It binds to the protein CD80, which is found on certain normal white blood cells and on white blood cells that are cancer. It is a type of monoclonal antibody.
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| NSC Number | 734532
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| PDQ_Closed_Trial_Search_ID | 285686
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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| CAS_Registry | 357613-77-5
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