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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2642
http://purl.obolibrary.org/obo/NCIT_C2642
|
|---|---|
| Preferred Name | Idronoxil |
| Definitions |
A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death. |
|---|---|
| prefLabel | Idronoxil
|
| label | Idronoxil
|
| PDQ_Closed_Trial_Search_ID | 38371
|
| code | C2642
|
| Has_Target | |
| prefixIRI | NCIT:C2642
|
| in_subset |
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| Display_Name | Idronoxil
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| Preferred_Name | Idronoxil
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| FDA_UNII_Code | 995FT1W541
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C15H12O3
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| Maps_To | Idronoxil
|
| CAS_Registry | 81267-65-4
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| NCI_Drug_Dictionary_ID | 38371
|
| Legacy Concept Name | Phenoxodiol
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38371
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1134444
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