Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2641
http://purl.obolibrary.org/obo/NCIT_C2641
Preferred Name

Canfosfamide Hydrochloride
Definitions
The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.
prefLabel
Canfosfamide Hydrochloride
label
Canfosfamide Hydrochloride
PDQ_Closed_Trial_Search_ID
38367
code
C2641
prefixIRI
NCIT:C2641
in_subset
Display_Name
Canfosfamide Hydrochloride
Preferred_Name
Canfosfamide Hydrochloride
FDA_UNII_Code
1LI341K7NQ
Contributing_Source
CTRP
FDA
Chemical_Formula
C26H40Cl4N5O10PS.HCl
Maps_To
Canfosfamide Hydrochloride
CAS_Registry
439943-59-6
NCI_Drug_Dictionary_ID
38367
Legacy Concept Name
TLK286
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38367
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C1258106
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