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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2634
http://purl.obolibrary.org/obo/NCIT_C2634
|
|---|---|
| Preferred Name | Digitoxin |
| Definitions |
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI) |
|---|---|
| prefLabel | Digitoxin
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| label | Digitoxin
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| CHEBI_ID | CHEBI:28544
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| PDQ_Closed_Trial_Search_ID | 38332
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| code | C2634
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| prefixIRI | NCIT:C2634
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| in_subset | |
| Preferred_Name | Digitoxin
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| FDA_UNII_Code | E90NZP2L9U
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| Contributing_Source | FDA
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| Chemical_Formula | C41H64O13
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| Maps_To | Digitoxin
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| CAS_Registry | 71-63-6
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| NSC Number | 7529
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| NCI_Drug_Dictionary_ID | 38332
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| Legacy Concept Name | Digitoxin
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38332
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| Accepted_Therapeutic_Use_For | Atrial Fibrillation; Atrial Flutter; Congestive Heart Failure; Supraventricular Tachyarrhythmias.
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0012258
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