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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2633
http://purl.obolibrary.org/obo/NCIT_C2633
|
|---|---|
| Preferred Name | Pelitrexol |
| Definitions |
A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation |
|---|---|
| prefLabel | Pelitrexol
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| label | Pelitrexol
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| PDQ_Closed_Trial_Search_ID | 38329
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| code | C2633
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| prefixIRI | NCIT:C2633
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| in_subset | |
| Preferred_Name | Pelitrexol
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| FDA_UNII_Code | DHT6E8M4KP
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| Contributing_Source | FDA
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| Chemical_Formula | C20H25N5O6S
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| Maps_To | Pelitrexol
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| CAS_Registry | 446022-33-9
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| NCI_Drug_Dictionary_ID | 38329
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| Legacy Concept Name | AG2037
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38329
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1871457
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