Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2630
http://purl.obolibrary.org/obo/NCIT_C2630
Preferred Name

Tucotuzumab Celmoleukin
Definitions
A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. Tucotuzumab Celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of the fusion protein may stimulate a cytotoxic T-cell antitumor immune response.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. Tucotuzumab Celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of the fusion protein may stimulate a cytotoxic T-cell antitumor immune response.
prefLabel
Tucotuzumab Celmoleukin
label
Tucotuzumab Celmoleukin
PDQ_Closed_Trial_Search_ID
456358
code
C2630
prefixIRI
NCIT:C2630
in_subset
Preferred_Name
Tucotuzumab Celmoleukin
FDA_UNII_Code
4ON7FF680U
Contributing_Source
FDA
Maps_To
Tucotuzumab Celmoleukin
CAS_Registry
339986-90-2
NCI_Drug_Dictionary_ID
456358
Legacy Concept Name
KSA-Interleukin-2_Fusion_Protein
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
456358
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C1721369
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