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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2618
http://purl.obolibrary.org/obo/NCIT_C2618
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|---|---|
| Preferred Name | Benzoylphenylurea |
| Definitions |
A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04) |
|---|---|
| prefLabel | Benzoylphenylurea
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| label | Benzoylphenylurea
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| PDQ_Closed_Trial_Search_ID | 38213
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| code | C2618
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| Has_Target | |
| prefixIRI | NCIT:C2618
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| in_subset |
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| Display_Name | Benzoylphenylurea
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| Preferred_Name | Benzoylphenylurea
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| FDA_UNII_Code | M10I9SO6RR
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Benzoylphenylurea
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| CAS_Registry | 1195179-46-4
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| NSC Number | 639829
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| NCI_Drug_Dictionary_ID | 38213
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| Legacy Concept Name | Benzoylphenylurea
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It is a type of antitubulin agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38213
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0935907
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