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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C26149
http://purl.obolibrary.org/obo/NCIT_C26149
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|---|---|
| Preferred Name | B-Cell Lymphoma 6 Protein |
| Definitions |
B-cell lymphoma 6 protein (706 aa, ~79 kDa) is encoded by the human BCL6 gene. This protein is involved in transcriptional repression, apoptosis regulation and cell cycle progression.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | B-cell lymphoma 6 protein (706 aa, ~79 kDa) is encoded by the human BCL6 gene. This protein is involved in transcriptional repression, apoptosis regulation and cell cycle progression. |
|---|---|
| prefLabel | B-Cell Lymphoma 6 Protein
|
| label | B-Cell Lymphoma 6 Protein
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| code | C26149
|
| prefixIRI | NCIT:C26149
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| OMIM_Number | 109565
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| in_subset | |
| Display_Name | B-Cell Lymphoma 6 Protein
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| Preferred_Name | B-Cell Lymphoma 6 Protein
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| Contributing_Source |
CTRP
GDC
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| Swiss_Prot | P41182
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| Maps_To | BCL6
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| Legacy Concept Name | B-Cell_Lymphoma-6_Protein
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| DesignNote | B-Cell Lymphoma 6 Protein is a zinc finger transcription factor containing an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. Target genes have roles in B-cell activation, B-cell differentiation, inflammation, and cell cycle control. Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. The BCL6 gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. (from OMIM, and LocusLink)
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1448774
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