C26122

D(1B) dopamine receptor (477 aa, ~53 kDa) is encoded by the human DRD5 gene. This protein plays a role in dopaminergic synaptic transmission and adenylate cyclase activation.

Dopamine Receptor D5, encoded by the human DRD5 gene, is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age.

D(1B) Dopamine Receptor

Dopamine_Receptor-D5

126453

D(1B) Dopamine Receptor

NCIT:C26122

D(1B) Dopamine Receptor

Amino Acid, Peptide, or Protein

Receptor

P21918

C1529472