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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C25859
http://purl.obolibrary.org/obo/NCIT_C25859
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|---|---|
| Preferred Name | Fibroblast Growth Factor Receptor 4 |
| Definitions |
Fibroblast growth factor receptor 4 (802 aa, ~88 kDa) is encoded by the human FGFR4 gene. This protein plays a role in the regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Fibroblast growth factor receptor 4 (802 aa, ~88 kDa) is encoded by the human FGFR4 gene. This protein plays a role in the regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. |
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| label | Fibroblast Growth Factor Receptor 4
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| prefLabel | Fibroblast Growth Factor Receptor 4
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| Legacy Concept Name | Fibroblast_Growth_Factor_Receptor-4
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| in_subset | |
| Preferred_Name | Fibroblast Growth Factor Receptor 4
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| Display_Name | Fibroblast Growth Factor Receptor 4
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| Swiss_Prot | P22455
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| DesignNote | Encoded by human FGFR4 Gene (FGFR Family), 802-amino acid 87.9 kD (precursor) type I membrane protein Fibroblast Growth Factor Receptor 4 is a receptor tyrosine kinase with three extracellular Ig-like C2-type domains, a cytoplasmic tyrosine kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. FGFR family amino acid sequence is highly conserved; the extracellular domain interacts with FGFs, signaling downstream cascades that influence mitogenesis and differentiation. FGFRs differ in ligand affinities and tissue distribution. Predominantly expressed in lung, FGFR4 expression is distinct from FLG, BEK, and FGFR3. Unlike FGFR1-3, FGFR4 IgIII domain C-terminal half does not vary. Although function is unknown, FGFR4 preferentially binds acidic FGF and FGF19; it does not bind to basic FGF. (from Swiss-Prot, OMIM, and NCI)
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| UMLS_CUI | C1565716
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| prefixIRI | NCIT:C25859
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C25859
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| type | |
| OMIM_Number | 134935
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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