Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C25842
http://purl.obolibrary.org/obo/NCIT_C25842
Preferred Name

Cyclin-Dependent Kinase 2
Definitions
Cyclin-dependent kinase 2 (298 aa, ~34 kDa) is encoded by the human CDK2 gene. This protein is involved in the regulation of both phosphorylation of cyclins and the cell cycle progression from the G2 phase to mitosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Cyclin-dependent kinase 2 (298 aa, ~34 kDa) is encoded by the human CDK2 gene. This protein is involved in the regulation of both phosphorylation of cyclins and the cell cycle progression from the G2 phase to mitosis.
label
Cyclin-Dependent Kinase 2
prefLabel
Cyclin-Dependent Kinase 2
Legacy Concept Name
Cyclin-Dependent_Kinase-2
in_subset
Preferred_Name
Cyclin-Dependent Kinase 2
Display_Name
Cyclin-Dependent Kinase 2
Swiss_Prot
P24941
DesignNote
This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (LocusLink, OMIM)
UMLS_CUI
C0108855
prefixIRI
NCIT:C25842
Contributing_Source
CTRP
subClassOf
code
C25842
type
OMIM_Number
116953
Semantic_Type
Amino Acid, Peptide, or Protein
Enzyme
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