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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C25795
http://purl.obolibrary.org/obo/NCIT_C25795
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|---|---|
| Preferred Name | Leukocyte Surface Antigen CD47 |
| Definitions |
Leukocyte surface antigen CD47 (323 aa, ~35 kDa) is encoded by the human CD47 gene. This protein plays a role in both cell adhesion and T-cell activation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Leukocyte surface antigen CD47 (323 aa, ~35 kDa) is encoded by the human CD47 gene. This protein plays a role in both cell adhesion and T-cell activation. |
|---|---|
| prefLabel | Leukocyte Surface Antigen CD47
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| label | Leukocyte Surface Antigen CD47
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| code | C25795
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| prefixIRI | NCIT:C25795
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| OMIM_Number | 601028
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| in_subset | |
| Display_Name | Leukocyte Surface Antigen CD47
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| Preferred_Name | Leukocyte Surface Antigen CD47
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| Contributing_Source | CTRP
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| Swiss_Prot | Q08722
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| Legacy Concept Name | CD47_Antigen
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| DesignNote | CD47 Antigen, encoded by the CD47 gene, is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C0220248
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