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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2570
http://purl.obolibrary.org/obo/NCIT_C2570
|
|---|---|
| Preferred Name | Arginine Butyrate |
| Definitions |
The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. (NCI04) |
|---|---|
| prefLabel | Arginine Butyrate
|
| label | Arginine Butyrate
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| PDQ_Closed_Trial_Search_ID | 42492
|
| code | C2570
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| prefixIRI | NCIT:C2570
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| in_subset | |
| Preferred_Name | Arginine Butyrate
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| FDA_UNII_Code | IK8S1P79MU
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| Contributing_Source | FDA
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| Chemical_Formula | 3C6H14N4O2.4C4H8O2
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| Maps_To | Arginine Butyrate
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| CAS_Registry | 80407-72-3
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| NCI_Drug_Dictionary_ID | 42492
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| Legacy Concept Name | Arginine_Butyrate
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42492
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0052329
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