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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2543
http://purl.obolibrary.org/obo/NCIT_C2543
|
|---|---|
| Preferred Name | Tositumomab |
| Definitions |
A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI04) |
|---|---|
| prefLabel | Tositumomab
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| label | Tositumomab
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| PDQ_Closed_Trial_Search_ID | 37818
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| code | C2543
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| Has_Target | |
| prefixIRI | NCIT:C2543
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| in_subset |
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| Display_Name | Tositumomab
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| Preferred_Name | Tositumomab
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| FDA_UNII_Code | 0343IGH41U
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Tositumomab
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| CAS_Registry | 192391-48-3
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| NCI_Drug_Dictionary_ID | 37818
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| Legacy Concept Name | Tositumomab
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| type | |
| ALT_DEFINITION | A monoclonal antibody that is used in the treatment of certain types of non-Hodgkin lymphoma. When tositumomab and iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine) are given together, the combination is called the Bexxar regimen.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 37818
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| Accepted_Therapeutic_Use_For | CD20 Positive Follicular Non-Hodgkins Lymphoma Refractory to Rituximab
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0879399
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