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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2541
http://purl.obolibrary.org/obo/NCIT_C2541
|
|---|---|
| Preferred Name | Y 90 Monoclonal Antibody HMFG1 |
| Definitions |
A radioimmunoconjugate consisting of HMFG1, a humanized monoclonal antibody directed against the tumor associated antigen mucin-1 (MUC-1), labeled with the beta-emitting radioisotope yttrium 90 (Y-90), with potential antineoplastic activities. Upon administration, the monoclonal antibody moiety targets and binds to MUC-1 on the surface of certain tumor cells. Upon binding and internalization, pemtumomab and delivers a cytotoxic dose of beta radiation to MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of HMFG1, a humanized monoclonal antibody directed against the tumor associated antigen mucin-1 (MUC-1), labeled with the beta-emitting radioisotope yttrium 90 (Y-90), with potential antineoplastic activities. Upon administration, the monoclonal antibody moiety targets and binds to MUC-1 on the surface of certain tumor cells. Upon binding and internalization, pemtumomab and delivers a cytotoxic dose of beta radiation to MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. |
|---|---|
| prefLabel | Y 90 Monoclonal Antibody HMFG1
|
| label | Y 90 Monoclonal Antibody HMFG1
|
| PDQ_Closed_Trial_Search_ID | 43644
|
| code | C2541
|
| prefixIRI | NCIT:C2541
|
| in_subset | |
| Preferred_Name | Y 90 Monoclonal Antibody HMFG1
|
| Maps_To | Y 90 Monoclonal Antibody HMFG1
|
| NCI_Drug_Dictionary_ID | 43644
|
| Legacy Concept Name | Y_90_Monoclonal_Antibody_HMFG1
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43644
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0879349
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| Delete | Subject | Author | Type | Created |
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