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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2530
http://purl.obolibrary.org/obo/NCIT_C2530
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|---|---|
| Preferred Name | DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98 |
| Definitions |
A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific inhibitor of translation of the mRNA for human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), hybridizing to the 3' un-translated region of DNMT1 mRNA. The silencing of DNMT1 translation by MG 98 may result in the prevention or reversal of abnormal methylation of tumor suppressor genes and ultimately in tumor growth inhibition or tumor regression.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific inhibitor of translation of the mRNA for human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), hybridizing to the 3' un-translated region of DNMT1 mRNA. The silencing of DNMT1 translation by MG 98 may result in the prevention or reversal of abnormal methylation of tumor suppressor genes and ultimately in tumor growth inhibition or tumor regression. |
|---|---|
| prefLabel | DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98
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| label | DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98
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| PDQ_Closed_Trial_Search_ID | 43475
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| code | C2530
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| prefixIRI | NCIT:C2530
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| in_subset | |
| Preferred_Name | DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98
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| Maps_To | DNMT1 Mixed-Backbone Antisense Oligonucleotide MG 98
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| NCI_Drug_Dictionary_ID | 43475
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| Legacy Concept Name | MG_98
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks the production of a protein called DNA methyltransferase, which helps control gene expression. This may kill cancer cells that need DNA methyltransferase to grow. It is a type of antisense oligonucleotide.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43475
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0796640
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