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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2527
http://purl.obolibrary.org/obo/NCIT_C2527
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|---|---|
| Preferred Name | Iodine I 131 Apamistamab |
| Definitions |
A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04) |
|---|---|
| prefLabel | Iodine I 131 Apamistamab
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| label | Iodine I 131 Apamistamab
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| PDQ_Closed_Trial_Search_ID | 43463
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| code | C2527
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| Has_Target | |
| prefixIRI | NCIT:C2527
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| in_subset |
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| Display_Name | Iodine I 131 Apamistamab
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| Preferred_Name | Iodine I 131 Apamistamab
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| FDA_UNII_Code | 71RR81V666
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Iodine I 131 Apamistamab
Iodine I 131 Monoclonal Antibody BC8
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| CAS_Registry | 2097132-02-8
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| NCI_Drug_Dictionary_ID | 43463
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| Legacy Concept Name | I_131_Monoclonal_Antibody_BC8
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| type | |
| ALT_DEFINITION | A monoclonal antibody that contains the radioactive substance iodine I131. It is being studied in the treatment of acute myeloid leukemia. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. Iodine I 131 monoclonal antibody BC8 binds to the protein CD45, which is found on most white blood cells and myeloid and lymphoid leukemia cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43463
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0796627
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