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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2499
http://purl.obolibrary.org/obo/NCIT_C2499
|
|---|---|
| Preferred Name | LMB-1 Immunotoxin |
| Definitions |
A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04) |
|---|---|
| prefLabel | LMB-1 Immunotoxin
|
| label | LMB-1 Immunotoxin
|
| PDQ_Closed_Trial_Search_ID | 43265
|
| code | C2499
|
| prefixIRI | NCIT:C2499
|
| in_subset | |
| Preferred_Name | LMB-1 Immunotoxin
|
| Maps_To | LMB-1 Immunotoxin
|
| NSC Number | 651311
|
| NCI_Drug_Dictionary_ID | 43265
|
| Legacy Concept Name | LMB-1_Immunotoxin
|
| type | |
| ALT_DEFINITION | A toxic substance linked to an antibody that attaches to tumor cells and kills them.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43265
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0796420
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