Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2454
http://purl.obolibrary.org/obo/NCIT_C2454
Preferred Name

Incyclinide
Definitions
A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
prefLabel
Incyclinide
label
Incyclinide
PDQ_Closed_Trial_Search_ID
42884
code
C2454
Has_Target
prefixIRI
NCIT:C2454
in_subset
Display_Name
Incyclinide
Preferred_Name
Incyclinide
FDA_UNII_Code
21G64WZQ4I
Contributing_Source
CTRP
FDA
Chemical_Formula
C19H17NO7
Maps_To
Incyclinide
CAS_Registry
15866-90-7
NSC Number
683551
NCI_Drug_Dictionary_ID
42884
Legacy Concept Name
COL-3
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. COL-3 may block the growth of new blood vessels that tumors need to grow. It is a type of matrix metalloproteinase inhibitor and a type of antiangiogenesis agent.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42884
Semantic_Type
Organic Chemical
Pharmacologic Substance
Antibiotic
UMLS_CUI
C0763138
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