Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2407
http://purl.obolibrary.org/obo/NCIT_C2407
Preferred Name

MUC-1 Antigen
Definitions
MUC-1 antigen is a mammary-type apomucin, a high molecular weight transmembrane glycoprotein, of which the extracellular domain is formed by a repeating 20 amino acid sequence (in tandem) with a high content of serine and threonine on which are O-linked carbohydrate chains. MUC-1 synthesis and secretion are features of glandular epithelial tissues; MUC-1 is overexpressed in lactating breast and in breast, ovary, lung, and prostate malignancies.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

MUC-1 antigen is a mammary-type apomucin, a high molecular weight transmembrane glycoprotein, of which the extracellular domain is formed by a repeating 20 amino acid sequence (in tandem) with a high content of serine and threonine on which are O-linked carbohydrate chains. MUC-1 synthesis and secretion are features of glandular epithelial tissues; MUC-1 is overexpressed in lactating breast and in breast, ovary, lung, and prostate malignancies.
prefLabel
MUC-1 Antigen
label
MUC-1 Antigen
PDQ_Closed_Trial_Search_ID
42454
code
C2407
prefixIRI
NCIT:C2407
in_subset
Display_Name
MUC-1 Antigen
Preferred_Name
MUC-1 Antigen
Contributing_Source
CTRP
NCI_Drug_Dictionary_ID
42454
Legacy Concept Name
MUC-1_Antigen
Related_To_Genetic_Biomarker
type
ALT_DEFINITION
A substance found on certain epithelial cells (cells that cover organs, glands, and other body surfaces) and on breast cells involved in making milk. It is also found on tumors of the breast, ovary, lung, and prostate. MUC-1 is a type of tumor marker.
subClassOf
PDQ_Open_Trial_Search_ID
42454
Semantic_Type
Amino Acid, Peptide, or Protein
Immunologic Factor
UMLS_CUI
C0006611
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