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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2405
http://purl.obolibrary.org/obo/NCIT_C2405
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|---|---|
| Preferred Name | Boronophenylalanine-Fructose Complex |
| Definitions |
A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues. |
|---|---|
| prefLabel | Boronophenylalanine-Fructose Complex
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| label | Boronophenylalanine-Fructose Complex
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| PDQ_Closed_Trial_Search_ID | 42404
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| code | C2405
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| prefixIRI | NCIT:C2405
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| in_subset | |
| Preferred_Name | Boronophenylalanine-Fructose Complex
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| Maps_To | Boronophenylalanine-Fructose Complex
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| NCI_Drug_Dictionary_ID | 42404
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| Legacy Concept Name | Boronophenylalanine-Fructose_Complex
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| type | |
| ALT_DEFINITION | A substance used in a type of radiation therapy called boron neutron capture therapy. BPA-F is injected into a vein, and becomes concentrated in tumor cells. The patient then receives radiation treatment with atomic particles called neutrons. The neutrons react with the boron in BPA-F, producing radioactive particles that kill the tumor cells without harming normal cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42404
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0289335
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